PSA Nitrogen Generator for Pharmaceutical Industry
Ensure product integrity, extend shelf life, and maintain GMP compliance with our high-purity on-site nitrogen generation systems designed specifically for pharmaceutical manufacturing facilities.
Why Nitrogen is Critical in Pharmaceutical Manufacturing
Nitrogen plays a vital role in maintaining product quality, safety, and regulatory compliance throughout pharmaceutical production processes.
Oxidation Prevention
Nitrogen creates an inert atmosphere that prevents oxidation of active pharmaceutical ingredients (APIs), preserving drug efficacy and extending shelf life of sensitive compounds.
Moisture Control
Dry nitrogen gas helps control humidity levels during manufacturing and storage, preventing moisture absorption that can degrade hygroscopic pharmaceutical products.
Modified Atmosphere Packaging
Nitrogen flushing in blister packs and bottles displaces oxygen, protecting light-sensitive and oxygen-sensitive medications from degradation during storage and distribution.
Reactor Blanketing
Nitrogen blanketing in synthesis reactors and vessels prevents explosive atmospheres, protects reactive intermediates, and ensures safe handling of volatile organic compounds.
Solvent Recovery
Nitrogen is used in solvent recovery systems to create safe, oxygen-free environments during distillation and recovery of pharmaceutical-grade solvents.
Freeze Drying Protection
Nitrogen provides an inert atmosphere during lyophilization processes, protecting biologics and injectable drugs from oxidative degradation during freeze-drying cycles.
Pharmaceutical Applications
Our PSA nitrogen generators serve critical applications across pharmaceutical manufacturing operations.
API Manufacturing & Synthesis
Nitrogen blanketing during active pharmaceutical ingredient production protects sensitive compounds from oxidation, maintains reaction conditions, and prevents contamination. Essential for synthesis of antibiotics, steroids, and other oxygen-sensitive APIs.
Tablet & Capsule Packaging
Nitrogen flushing in blister packaging and bottle filling lines displaces oxygen to extend product shelf life. Critical for moisture-sensitive tablets, gelatin capsules, and effervescent formulations that require protection from humidity and oxidation.
Sterile Injectable Production
High-purity nitrogen for aseptic filling operations, vial purging, and headspace replacement in injectable drug manufacturing. Maintains sterility while preventing oxidation of parenteral formulations and biologics.
Storage Tank Blanketing
Continuous nitrogen blanketing of bulk storage tanks containing raw materials, intermediates, and finished products. Prevents oxidation, moisture ingress, and maintains product stability during long-term storage.
Lyophilization (Freeze Drying)
Nitrogen atmosphere during freeze-drying of vaccines, antibodies, and other biologics. Protects heat-sensitive and oxygen-sensitive pharmaceutical products during the lyophilization cycle and subsequent storage.
Powder Handling & Transfer
Nitrogen purging during pneumatic transfer of pharmaceutical powders prevents dust explosions, controls static electricity, and maintains product quality. Essential for handling fine powders and potent compounds in contained transfer systems.
Glove Box & Isolator Purging
High-purity nitrogen for purging and maintaining inert atmospheres in pharmaceutical isolators and glove boxes used for handling highly potent APIs, cytotoxic compounds, and oxygen-sensitive materials.
Benefits of On-Site Nitrogen Generation
Eliminate dependency on cylinder or liquid nitrogen suppliers with our reliable on-site generation systems.
Cost Savings
- •Reduce nitrogen costs by up to 70% compared to cylinder or liquid nitrogen supply
- •Eliminate delivery charges, rental fees, and cylinder handling costs
- •Typical ROI within 12-24 months for pharmaceutical facilities
- •Predictable operating costs with minimal maintenance requirements
Reliability & Availability
- •24/7 nitrogen supply eliminates risk of running out during critical operations
- •No dependency on external suppliers or delivery schedules
- •Redundant system designs available for mission-critical applications
- •Rapid startup time of only 15 minutes from cold start
Safety & Compliance
- •Eliminate hazards associated with handling high-pressure cylinders
- •No cryogenic liquid nitrogen storage risks or special handling requirements
- •Reduced facility footprint and simplified regulatory compliance
- •GMP-compliant design with full documentation and validation support
Quality & Purity
- •Consistent purity levels from 95% to 99.9999% based on requirements
- •Continuous online purity monitoring with oxygen analyzer
- •Dry nitrogen output with dew point down to -40°C or lower
- •Oil-free nitrogen when used with oil-free air compressors
Technical Specifications
Our pharmaceutical-grade nitrogen generators meet the stringent requirements of the pharmaceutical industry.
Purity Levels
Standard Pharmaceutical Grade
99.5% - 99.9% nitrogen purity, suitable for most pharmaceutical applications including packaging, blanketing, and general inerting.
High Purity Grade
99.99% - 99.999% nitrogen purity for critical applications such as API synthesis, sterile injectable production, and sensitive compound handling.
Ultra-High Purity Grade
Up to 99.9999% (less than 1 ppm oxygen) with additional purification for the most demanding applications including biologics and highly reactive compounds.
Customized Purity
Tailored purity levels to match specific process requirements and regulatory standards.
System Capacities
- Small Scale: 1-50 Nm³/hr for laboratory and pilot plant applications
- Medium Scale: 50-500 Nm³/hr for packaging lines and batch manufacturing
- Large Scale: 500-2000 Nm³/hr for full-scale production facilities
- Custom Capacity: Higher flow rates available for multi-building campuses and large pharmaceutical complexes
Operating Parameters
Outlet Pressure
4-7 bar(g) standard, customizable up to 10 bar(g)
Dew Point
-40°C to -70°C (with optional dryer upgrade)
Startup Time
15 minutes from cold start to rated purity
Power Consumption
0.4-0.6 kWh per Nm³ of nitrogen produced
Compliance & Quality Standards
Our nitrogen generation systems are designed to meet pharmaceutical industry regulations and quality standards.
GMP Compliance
Our systems are designed and manufactured in accordance with Good Manufacturing Practice (GMP) guidelines to ensure pharmaceutical-grade nitrogen production.
Documentation & Validation
- •Complete Factory Acceptance Test (FAT) documentation
- •Installation Qualification (IQ) protocols and reports
- •Operational Qualification (OQ) support and documentation
- •Performance Qualification (PQ) assistance
- •Material certificates and traceability documentation
Design Features
- •Sanitary design with cleanable surfaces
- •316L stainless steel construction for product contact parts
- •Continuous purity monitoring with alarms
- •Data logging and audit trail capabilities
- •Validated cleaning procedures
Note: We provide comprehensive support throughout the validation process, including technical documentation, on-site commissioning, and training to ensure your nitrogen generation system meets all regulatory requirements and internal quality standards.
Why Choose Gastek Engineering
Trusted partner for pharmaceutical nitrogen generation solutions.
Technical Collaboration with CarboTech, Germany
We manufacture PSA nitrogen plants using premium Carbon Molecular Sieves from CarboTech, ensuring superior performance and longevity.
Pharmaceutical Industry Experience
Extensive experience supplying nitrogen generation systems to pharmaceutical manufacturers across India and internationally.
Customized Solutions
Every system is tailored to your specific requirements, from capacity and purity to integration with existing infrastructure.
Comprehensive Support
From initial consultation through installation, commissioning, validation, and ongoing maintenance, we support you at every stage.
Quality Assurance
Rigorous quality control processes and testing ensure every system meets our high standards and your specifications.
After-Sales Service
Dedicated technical support team, spare parts availability, and preventive maintenance programs to ensure optimal system performance.
Ready to Enhance Your Pharmaceutical Production?
Contact our pharmaceutical nitrogen specialists today to discuss your specific requirements and discover how our PSA nitrogen generators can improve your operations.